MUSCLE-RELAXANT PROPERTIES OF IDENTIFIED METABOLITES OF DANTROLENE

被引：19

作者：

ELLIS, KO

WESSELS, FL

机构：

[1] Division of Morton-Norwich Products, Inc., Scientific Affairs Department, Norwich-Eaton Pharmaceuticals, Norwich, 13815, New York

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 1978年 / 301卷 / 03期

关键词：

5-Hydroxydantrolene; Dantrolene; Skeletal muscle relaxant;

D O I：

10.1007/BF00507042

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Identified metabolites of dantrolene, a skeletal muscle relaxant, were studied for inhibition of skeletal muscle contractions. Inhibition of muscle contractions were studied in vivo in the rat gastrocnemius muscle preparation, and in vitro using isolated rat diaphragm strips. Dantrolene (D) and 5-hydroxydantrolene (5-HD) inhibited muscle contraction responses in a dose dependent manner, both in vivo and in vitro. 5-HD was less potent than D. © 1978 Springer-Verlag.

引用

页码：237 / 240

页数：4

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