EVALUATION OF A NEW ANIMAL METHOD FOR PREDICTION OF CLINICAL ANTI-DEPRESSANT ACTIVITY

被引：23

作者：

SANGHVI, I

BINDLER, E

GERSHON, S

机构：

[1] Neuropsychopharmacology Research Unit, Department of Psychiatry New York University School of Medicine, New York

来源：

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY | 1969年 / 8卷 / 1P1期

关键词：

D O I：

10.1016/0024-3205(69)90298-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A new animal method has been evaluated to predict clinically useful anti-depressant agents. The test relies on the potentiating effects of anti-depressants on the behavioral and physiological changes induced by YOH in the conscious dog. Two agents, BL-KR 140 and EXP-561, which were predicted to be useful anti-depressant agents from the animal tests, failed to potentiate YOH induced changes, unlike IMI. Clinically also they were found to lack any anti-depressant activity. It is proposed that this test should be further evaluated employing established and potential anti-depressant agents. © 1969.

引用

页码：99 / &

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