INCREASED ECTOPIC ACTION-POTENTIAL GENERATION ACCOMPANIES EPILEPTOGENESIS INVITRO

被引：21

作者：

STASHEFF, SF

WILSON, WA

机构：

[1] DUKE UNIV,DEPT MED,DURHAM,NC 27705

[2] DUKE UNIV,DEPT PHARMACOL,DURHAM,NC 27705

来源：

NEUROSCIENCE LETTERS | 1990年 / 111卷 / 1-2期

关键词：

Action potential; Baseline spike; Ectopic; Epilepsy; Hippocampal slice; Intracellular; Prepotential; Seizure;

D O I：

10.1016/0304-3940(90)90359-H

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied changes in the characteristics of action potentials of CA3 pyramidal cells accompanying electrographic seizure (EGS) induction, using an in vitro model similar to kindling. We found an increased propensity to fire action potentials which lack EPSPs or other triggering depolarizing potentials. Such 'baseline spikes' appear to be initiated at a site electrically distant from the soma. © 1990.

引用

页码：144 / 150

页数：7

共 20 条

[1]

[Anonymous], [No title captured]

[2]

BENARDO LS, 1982, J NEUROSCI, V2, P1614

[3]

BERNARD E, IN PRESS BRAIN RES

[4] BENZODIAZEPINE-INDUCED EPILEPTIFORM ACTIVITY INVITRO [J].