ROLE OF EXOGENOUS HISTAMINE IN SCOMBROID POISONING

被引：30

作者：

MOTIL, KJ

SCRIMSHAW, NS

机构：

[1] Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge

来源：

TOXICOLOGY LETTERS | 1979年 / 3卷 / 04期

关键词：

D O I：

10.1016/0378-4274(79)90037-7

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

To investigate the role of histamine [which is postulated to result from bacterial action on free histidine in muscle of scombroid fish] as a caustive factor in scombroid poisoning, 4 subjects received grapefruit juice with or without graded doses of histamine in a randomized double-blind fashion for 10 days. Subjects (8) received tuna sandwiches with or without histamine in the same manner. Clinical symptoms and vital signs were recorded daily. Histaminase activity was measured in plasma eosinophils and serum. Although vital signs and histaminase activity showed no consistent pattern of change at any histamine dose, characteristic symptoms of scombroid poisoning (severe headaches and facial flushing) were noted at the 100-, 150- and 180-mg doses of histamine. Histamine may be responsible for the symptoms seen in scombroid poisoning.

引用

页码：219 / 223

页数：5

共 18 条

[1]

AISO K, 1958, JAPAN J MICROBIOL, V2, P143

[2]

DOUGLAS WW, 1970, PHARMACOL BASIS, P621

[3]

FERENCIK M, 1970, J HYG EPID MICROB IM, V14, P52

[4]

GRANERUS G, 1968, SCAND J CLIN LAB INV, VS 22, P49

[5]

HALSTED BW, 1967, POISONOUS VENOMOUS M, V2, P639

[6]

HUDSON S, ADV FOOD RES

[7]

KAWABATA T, 1955, Jpn J Med Sci Biol, V8, P487

[8]

KIMATA M, 1960, MEM RES I FOOD SCI, V20, P1

[9]

LEGROUX R, 1946, PRESSE MED, V54, P545

[10] EFFECT OF DIET ON URINARY EXCRETION OF HISTAMINE [J].

MITCHELL, RG ;

CODE, CF .

JOURNAL OF APPLIED PHYSIOLOGY, 1954, 6 (07) :387-392

← 1 2 →