SYNTHESIS OF BENZO-15-CROWN-5 POLYETHERS, ANTICOCCIDIAL IONOPHORE ANALOGS

被引：18

作者：

BROWN, GR

FOUBISTER, AJ

机构：

[1] Imperical Chemical Industries Limited, Pharmaceuticals Division, Alderley Park, Macclesfield, Cheshire

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 08期

关键词：

D O I：

10.1021/jm00194a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of eight benzo-15-crown-5 derivatives I (R = H, CO2Me, CO2H, Me; Rx = H, CO2H, CO2Me, CHO, CH̿CHCO2H, CH2CH2CO2H) designed as rigid cyclic analogues of the anticoccidial ionophores is described. No anticoccidial activity was observed in chickens, but moderate activity in tissue culture was found for I (R = Me, R1= H; R = R1= H) and dibenzo-18-crown-6. © 1979, American Chemical Society. All rights reserved.

引用

页码：997 / 999

页数：3

共 10 条

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