SYNTHESIS AND EVALUATION OF NEW PROTEIN-TYROSINE KINASE INHIBITORS .2. PHENYLHYDRAZONES

被引：17

作者：

CUSHMAN, M

NAGARATHNAM, D

GOPAL, D

GEAHLEN, RL

机构：

[1] Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)80255-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 33 phenylhydrazone derivatives of polyhydroxylated benzaldehydes has been prepared and tested for inhibition of the protein-tyrosine kinase p56lck. The most potent of these compounds was a competitive inhibitor of p56lck with respect to a tyrosine-containing peptide substrate and was similar in potency to piceatannol, a naturally occurring protein-tyrosine kinase inhibitor.

引用

页码：215 / 218

页数：4

共 11 条

[1] CHERONIS ND, 1965, SEMIMICRO QUALITATIV, P741
[2] CHERONIS ND, 1963, IDENTIFICATION ORGAN, P368
[3] SYNTHESIS AND PROTEIN-TYROSINE KINASE INHIBITORY ACTIVITIES OF FLAVONOID ANALOGS
CUSHMAN, M
NAGARATHNAM, D
BURG, DL
GEAHLEN, RL
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) : 798 - 806
[4] USE OF POTATO DISK AND BRINE SHRIMP BIOASSAYS TO DETECT ACTIVITY AND ISOLATE PICEATANNOL AS THE ANTILEUKEMIC PRINCIPLE FROM THE SEEDS OF EUPHORBIA-LAGASCAE
FERRIGNI, NR
MCLAUGHLIN, JL
POWELL, RG
SMITH, CR
[J]. JOURNAL OF NATURAL PRODUCTS, 1984, 47 (02): : 347 - 352
[5] PICEATANNOL (3,4,3',5'-TETRAHYDROXY-TRANS-STILBENE) IS A NATURALLY-OCCURRING PROTEIN-TYROSINE KINASE INHIBITOR
GEAHLEN, RL
MCLAUGHLIN, JL
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (01) : 241 - 245
[6] KINETIC-STUDIES OF TYROSINE KINASE INHIBITION BY ERBSTATIN
IMOTO, M
UMEZAWA, K
ISSHIKI, K
KUNIMOTO, S
SAWA, T
TAKEUCHI, T
UMEZAWA, H
[J]. JOURNAL OF ANTIBIOTICS, 1987, 40 (10) : 1471 - 1473
[7] The synthesis of the three isomeric dl-beta-pyridylalanines
Niemann, C
Lewis, RN
Hays, JT
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1942, 64 : 1678 - 1682
[8] SHIRAISHI T, 1989, CANCER RES, V49, P2374
[9] INHIBITION OF EPIDERMAL GROWTH FACTOR-INDUCED DNA-SYNTHESIS BY TYROSINE KINASE INHIBITORS
UMEZAWA, K
HORI, T
TAJIMA, H
IMOTO, M
ISSHIKI, K
TAKEUCHI, T
[J]. FEBS LETTERS, 1990, 260 (02) : 198 - 200
[10] WIBAUT JP, 1945, RECL TRAV CHIM PAY B, V64, P30

← 1 2 →