GAS-CHROMATOGRAPHY NEGATIVE-ION CHEMICAL IONIZATION TANDEM MASS-SPECTROMETRIC QUANTIFICATION OF INDOMETHACIN IN PLASMA AND SYNOVIAL-FLUID

被引:9
作者
DAWSON, M
SMITH, MD
MCGEE, CM
机构
[1] Department of Rheumatology, Royal North Shore Hospital, St Leonards, New South Wales
来源
BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY | 1990年 / 19卷 / 08期
关键词
D O I
10.1002/bms.1200190802
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
A procedure for the quantification of sub‐nanogram per millilitre concentrations of indomethacin in plasma and synovial fluid has been developed using gas chromatography/negative ion chemical ionization/tandem mass spectrometry. The procedure is based on selected ion monitoring of the daughter ion at m/z 312 generated following decarboxylation of the 35Cl isotope peak of the indomethacin anion (m/z 356) formed from the pentafluorobenzyl ester of indomethacin in the ion source of the mass spectrometer. The internal standard, d2‐indomethacin, has a daughter ion at m/z 316 formed from the corresponding 37Cl isotope peak. The limit of quantification was 0.1 ng ml−1 for both plasma and synovial fluid. Copyright © 1990 John Wiley & Sons, Ltd.
引用
收藏
页码:453 / 458
页数:6
相关论文
共 9 条
[1]  
BERINGER IW, 1986, J CLIN CHEM BIOCH, V24, P227
[2]  
BOARDMAN PL, 1976, ANN RHEUM DIS, V26, P127
[3]   SYNTHESIS OF DEUTERATED ARYLALKANOIC ACIDS FOR USE AS INTERNAL STANDARDS IN GAS CHROMATOGRAPHY/MASS SPECTROMETRY ASSAYS FOR NON-STEROIDAL ANTI-INFLAMMATORY DRUGS [J].
DAWSON, M ;
MCGEE, CM ;
SMITH, MD ;
VINE, JH .
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1989, 27 (06) :707-714
[4]   QUANTIFICATION OF LEUKOTRIENE-B4 IN SYNOVIAL-FLUID BY GAS-CHROMATOGRAPHY TANDEM MASS-SPECTROMETRY [J].
DAWSON, M ;
MCGEE, CM ;
BROOKS, PM ;
VINE, JH ;
WATSON, TR .
BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY, 1988, 17 (03) :205-211
[5]   THE DISPOSITION OF BIPHENYLACETIC ACID FOLLOWING TOPICAL APPLICATION [J].
DAWSON, M ;
MCGEE, CM ;
VINE, JH ;
NASH, P ;
WATSON, TR ;
BROOKS, PM .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 33 (06) :639-642
[6]   SIMULTANEOUS PHARMACOKINETICS OF INDOMETHACIN IN SERUM AND SYNOVIAL-FLUID [J].
EMORI, HW ;
CHAMPION, GD ;
PAULUS, HE .
ANNALS OF THE RHEUMATIC DISEASES, 1973, 32 (05) :433-435
[7]  
PRATZEL H, 1986, J RHEUMATOL, V13, P1122
[8]  
SUBBS RJ, 1986, J CHROMATOGR, V383, P432
[9]   INHIBITION OF PROSTAGLANDIN SYNTHESIS AS A MECHANISM OF ACTION FOR ASPIRIN-LIKE DRUGS [J].
VANE, JR .
NATURE-NEW BIOLOGY, 1971, 231 (25) :232-&