ATTRACTION OF HUMAN MONOCYTES BY THE NEUROPEPTIDE SECRETONEURIN

被引：116

作者：

REINISCH, N

KIRCHMAIR, R

KAHLER, CM

HOGUEANGELETTI, R

FISCHERCOLBRIE, R

WINKLER, H

WIEDERMANN, CJ

机构：

[1] UNIV INNSBRUCK, DEPT PHARMACOL, PETER MAYR STR 1A, A-6020 INNSBRUCK, AUSTRIA

[2] UNIV INNSBRUCK, DEPT INTERNAL MED, A-6020 INNSBRUCK, AUSTRIA

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT DEV & MOLEC BIOL, BRONX, NY 10461 USA

来源：

FEBS LETTERS | 1993年 / 334卷 / 01期

关键词：

SECRETONEURIN; SECRETOGRANIN-II; NEUROGENIC INFLAMMATION; CHEMOTAXIS; MONOCYTE;

D O I：

10.1016/0014-5793(93)81676-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Secretoneurin is a newly discovered 33-amino-acid peptide derived from secretogranin II (chromogranin C) that is found in sensory afferent C-fibers. We show here that secretoneurin triggers the selective migration of human monocytes in vitro and in vivo. Combinations of secretoneurin with the sensory neuropeptides, substance P or somatostatin, synergistically stimulate such migration. The attraction of monocytes represents the first established function of secretoneurin as a sensory neuropeptide.

引用

页码：41 / 44

页数：4

共 16 条

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