SHORT-TERM EFFECTS OF ELECTROCONVULSIVE TREATMENT ON THE UPTAKE OF TC-99M EXAMETAZIME INTO BRAIN IN MAJOR DEPRESSION SHOWN WITH SINGLE-PHOTON EMISSION TOMOGRAPHY

被引：56

作者：

SCOTT, AIF ^{[1
]}

DOUGALL, N ^{[1
]}

ROSS, M ^{[1
]}

OCARROLL, RE ^{[1
]}

RIDDLE, W ^{[1
]}

EBMEIER, KP ^{[1
]}

GOODWIN, GM ^{[1
]}

机构：

[1] ROYAL EDINBURGH & ASSOCIATED HOSP, MRC, BRAIN METAB UNIT, MORNINGSIDE PK, EDINBURGH EH10 5HF, SCOTLAND

来源：

JOURNAL OF AFFECTIVE DISORDERS | 1994年 / 30卷 / 01期

基金：

英国惠康基金;

关键词：

ELECTROCONVULSIVE THERAPY; ELECTROCONVULSIVE SHOCK; UNIPOLAR DEPRESSIVE ILLNESS; SPECT; EXAMETAZIME; CINGULATE CORTEX;

D O I：

10.1016/0165-0327(94)90148-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fifteen patients with major depression who were being treated with bilateral electroconvulsive treatment (ECT) were investigated before and 45 min after a single ECT using split-dose Single Photon Emission Tomography (SPET or SPECT) with Tc-99m-Exametazime. All patients suffered from unipolar depressive illness and were rated on the Newcastle scale and with the 17-item Hamilton scale. They completed tests of orientation and verbal memory on the day of ECT. For comparison, verbal memory was also tested on the preceding day. The uptake of Tc-99m-Exametazime was expressed relative to calcarine/occipital cortex. Significant decreases in tracer uptake were confined to the inferior anterior cingulate cortex. The changes were correlated with the severity of depressive symptoms and more weakly with decrements of memory function produced by ECT; there was no significant correlation with stimulus intensity or electroencephalographic measures of seizure duration.

引用

页码：27 / 34

页数：8

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