PEPTIDE-T, A NOVEL BRADYKININ POTENTIATOR ISOLATED FROM TITYUS-SERRULATUS SCORPION-VENOM

被引：64

作者：

FERREIRA, LAF ^{[1
]}

ALVES, EW ^{[1
]}

HENRIQUES, OB ^{[1
]}

机构：

[1] UNIV FED RIO DE JANEIRO,DEPT BIOQUIM,RIO JANEIRO,BRAZIL

来源：

TOXICON | 1993年 / 31卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/0041-0101(93)90253-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A bradykinin-potentiating peptide was isolated and characterized from venom of the scorpion Tityus serrulatus by chromatographic techniques followed by biological assays. The complete amino acid sequence (13 residues) of peptide is presented. The peptide potentiated the contractile activity of bradykinin on the isolated guinea-pig ileum, and inhibited the hydrolysis of bradykinin by angiotensin-converting enzyme from B. jararaca plasma and the conversion of angiotensin I to angiotensin II by kininase II from guinea-pig ileum tissue. The peptide also increased the depressor effect of bradykinin on arterial blood pressure in the anaesthetized rat.

引用

页码：941 / 947

页数：7

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