THE OCTAMER BINDING-PROTEIN OCT-2 INHIBITS TRANSACTIVATION OF THE HERPES-SIMPLEX VIRUS IMMEDIATE-EARLY GENES BY THE VIRION PROTEIN VMW65

被引：30

作者：

LILLYCROP, KA ^{[1
]}

ESTRIDGE, JK ^{[1
]}

LATCHMAN, DS ^{[1
]}

机构：

[1] UCL, SCH MED,DIV MOLEC PATHOL,WINDEYER BLDG, CLEVELAND ST, LONDON W1P 6DB, ENGLAND

来源：

VIROLOGY | 1993年 / 196卷 / 02期

关键词：

D O I：

10.1006/viro.1993.1552

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Transactivation by a complex of the cellular transcription factor Oct-1 and the virion protein Vmw65 is necessary for the high-level activity of the HSV immediate-early promoters during lytic infection. We show that this trans-activation can be inhibited by two forms of the Oct-2 transcription factor which are expressed at high levels in neuronal cells as well as by the isolated DNA binding, POU domain of Oct-2. The inhibition of Oct-1-Vmw65 DNA binding by these neuronal forms of Oct-2 is likely to play a critical role in the nonpermissivity of neuronal cells for the HSV lytic cycle and therefore in the establishment of latent infections. © 1993 by Academic Press, Inc.

引用

页码：888 / 891

页数：4

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