SUPPRESSION OF SIMIAN IMMUNODEFICIENCY VIRUS-REPLICATION BY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TRANSDOMINANT NEGATIVE REV MUTANTS

被引：7

作者：

ENDRES, CL

BERGQUAM, EP

AXTHELM, MK

WONG, SW

机构：

[1] OREGON REG PRIMATE RES CTR,DIV PATHOBIOL & IMMUNOL,BEAVERTON,OR 97006

[2] OREGON HLTH SCI UNIV,DEPT MOLEC MICROBIOL & IMMUNOL,PORTLAND,OR 97201

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 08期

关键词：

D O I：

10.1128/JVI.69.8.5164-5166.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We demonstrate that trans-dominant negative rev mutants are able to suppress simian immunodeficiency virus provirus replication in both transient cotransfection assays and stably transduced HUT 78 cells. These studies suggest that the efficacy of trans-dominant rev strategies in reducing viral burden may be evaluated in a simian immunodeficiency virus-rhesus macaque animal model.

引用

收藏

页码：5164 / 5166

页数：3

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