A METAANALYSIS OF BODY-MASS INDEX AND RISK OF PREMENOPAUSAL BREAST-CANCER

被引：188

作者：

URSIN, G

LONGNECKER, MP

HAILE, RW

GREENLAND, S

机构：

[1] Department of Epidemiology, School of Public Health, Center for the Health Sciences, University of California, Los Angeles, CA

[2] Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles, CA

来源：

EPIDEMIOLOGY | 1995年 / 6卷 / 02期

关键词：

META ANALYSIS; BODY MASS; BREAST NEOPLASMS;

D O I：

10.1097/00001648-199503000-00009

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Increased body mass index (BMI) has been found to be associated with elevated risk of postmenopausal breast cancer. Whether BMI is related to premenopausal breast cancer has not yet been established. We performed a meta-analyses of data from 23 studies that provided information on BMI and incidence of premenopausal breast cancer. Overall, the data support a modest inverse association. For a BMI difference of 8 kg per m(2), that is, the difference between a thin person and someone who is morbidly obese, the random effects estimate of the rate ratio from the four cohort studies was 0.70 [95% confidence interval (CI) = 0.54-0.91], and the random effects estimate of the odds ratio from the 19 case control studies was 0.88 (95% CI = 0.76-1.02). Because of substantial heterogeneity among the study-specific estimates, however, we also examined the influence of certain aspects of study design. Case-control studies with community controls had a more inverse association, whereas case-control studies that inter viewed cases shortly after diagnosis applied the same exclusion criteria to cases and controls, or with confounder adjustment beyond age had a more positive association between BMI and breast cancer. Possible reasons for the discrepancies among the case-control studies are discussed.

引用

页码：137 / 141

页数：5

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