DISTRIBUTION OF MU-OPIOID RECEPTORS IN THE NUCLEUS RAPHE MAGNUS AND NUCLEUS GIGANTOCELLULARIS - A QUANTITATIVE AUTORADIOGRAPHIC STUDY

被引：31

作者：

BOWKER, RM ^{[1
]}

DILTS, RP ^{[1
]}

机构：

[1] WASHINGTON STATE UNIV, DEPT VET & COMPARAT ANAT PHARMACOL & PHYSIOL, PULLMAN, WA 99164 USA

来源：

NEUROSCIENCE LETTERS | 1988年 / 88卷 / 03期

关键词：

D O I：

10.1016/0304-3940(88)90218-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study has described and quantitated the distribution of .mu.-opioid receptors in the nucleus raphe magnus (NRM) and nucleus gigantocellularis (NGC), using in vitro autoradiography. Moderately dense binding of a .mu.-enkephalin analog, DAGO, was observed in the NRM and adjacent parts of the NGC. DAGO binding density was greatest in the anterior NRM, possibly due to a greater involvement in the descending, opiate-mediated modulation of nociception. These findings agree with proposed roles for this region in the central regulation of pain.

引用

页码：247 / 252

页数：6

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