MECHANISM OF THE HYPOCALCEMIC EFFECT OF MITHRAMYCIN

被引：43

作者：

KIANG, DT

LOKEN, MK

KENNEDY, BJ

机构：

[1] UNIV MINNESOTA, SCH MED, DEPT MED, MED ONCOL SECT, MINNEAPOLIS, MN 55455 USA

[2] UNIV MINNESOTA, SCH MED, DEPT RADIOL, DIV NUCL RADIOL, MINNEAPOLIS, MN 55455 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1979年 / 48卷 / 02期

关键词：

D O I：

10.1210/jcem-48-2-341

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mithramycin is effective in the treatment of hypercalcemia. The mechanism of its hypocalcemic effect was studied in six patients with hypercalcemia by serum85Sr or45Ca kinetic techniques. Mithramycin was given at two dosage levels (25 or 50 μg/kg iv). Mithramycin at the low dosage had little effect on the rate of bone accretion. However, at both dosage levels, mithramycin caused an upward shift of the slope of the specific activity curve, indicating an inhibitory effect on bone resorption. This effect started 6-12 h after a 25-μg/kg dose of mithramycin and lasted from 4-6 days. It appears that mithramycin has a preferential effect on bone resorption. © 1979 by The Endocrine Society.

引用

页码：341 / 344

页数：4

共 17 条

[1] MITHRAMYCIN EFFECTS ON CALCIUM, PHOSPHORUS AND PARATHYROID-HORMONE IN OSSEOUS PAGETS-DISEASE [J].