STUDIES ON THE DISTRIBUTION OF C-14 SULPIRIDE AND ITS METABOLITES IN THE RAT AND GUINEA-PIG

被引：7

作者：

DROSS, K ^{[1
]}

HOPF, A ^{[1
]}

机构：

[1] UNIV DUSSELDORF,INST HIRNFORSCH,D-4000 DUSSELDORF 1,FED REP GER

来源：

PHARMAKOPSYCHIATRIE NEURO-PSYCHOPHARMAKOLOGIE | 1979年 / 12卷 / 06期

关键词：

D O I：

10.1055/s-0028-1094641

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

After ip. injection of 14C-labelled sulpiride in rats, about one third is metabolized while the other two thirds are excreted unchanged in feces and urine. The highest level of its metabolites was found in the liver (about 65% of total radioactivity). In the brain, 90% of the radioactivity consisted of unchanged sulpiride, which seems to be responsible for the central effects of the drug. The highest concentrations within the brain were found in the median eminence, circumventricular organs, plexus, and pineal body.

引用

页码：438 / 444

页数：7

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