HEPATIC PHASE OF MALARIA IS THE TARGET OF CELLULAR MECHANISMS INDUCED BY THE PREVIOUS AND THE SUBSEQUENT STAGES - A CRUCIAL ROLE FOR LIVER NONPARENCHYMAL CELLS

被引：36

作者：

MAZIER, D

RENIA, L

NUSSLER, A

PIED, S

MARUSSIG, M

GOMA, J

GRILLOT, D

MILTGEN, F

DRAPIER, JC

CORRADIN, G

DELGIUDICE, G

GRAU, GE

机构：

[1] UNIV GENEVA,WHO,CTR IMMUNOL RES & TRAINING,DEPT PATHOL,CH-1211 GENEVA 4,SWITZERLAND

[2] MUSEUM NATL HIST NAT,F-75231 PARIS 05,FRANCE

[3] UNIV LAUSANNE,INST BIOCHEM,CH-1000 LAUSANNE 17,SWITZERLAND

[4] INST CURIE,INSERM,U196,F-75231 PARIS 05,FRANCE

[5] GRP HOSP PITIE SALPETRIERE,DEPT PARASITOL,F-75634 PARIS 13,FRANCE

来源：

IMMUNOLOGY LETTERS | 1990年 / 25卷 / 1-3期

关键词：

ADCC; CD4[!sup]+[!/sup] T cells; Cytokines; Hepatic stages; Liver nonparenchymal cells (NPC); Malaria;

D O I：

10.1016/0165-2478(90)90093-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-γ, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity against pre-erythrocytic stages is clearly established. The potential interest of triggering peptide-primed CD4+ T cells has to be considered regarding protection. Indeed, CD4+ T cells induced by the non-repetitive part of the CS protein of Plasmodium yoelii are protective, by eliminating malaria from hepatocytes. The crucial role of the liver NPC has to be emphasized, their participation in TNF schizonticidal effect and in ADCC mechanisms being strongly supported by our data. © 1990.

引用

页码：65 / 70

页数：6

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