INTERSTITIAL HYPERTHERMIA OF MALIGNANT BRAIN-TUMORS BY IMPLANT HEATING-SYSTEM - CLINICAL-EXPERIENCE

被引：38

作者：

KOBAYASHI, T

KIDA, Y

TANAKA, T

HATTORI, K

MATSUI, M

AMEMIYA, Y

机构：

[1] NAGOYA UNIV,SCH MED,DEPT NEUROSURG,NAGOYA,AICHI 466,JAPAN

[2] NAGOYA UNIV,SCH TECHNOL,DEPT IRON & STEEL ENGN,NAGOYA,AICHI 464,JAPAN

[3] CHIBA INST TECHNOL,DEPT ELECT ENGN,NARASHINO,CHIBA 275,JAPAN

来源：

JOURNAL OF NEURO-ONCOLOGY | 1991年 / 10卷 / 02期

关键词：

INTERSTITIAL HYPERTHERMIA; IMPLANT HEATING SYSTEM (IHS); MALIGNANT BRAIN TUMOR; FE-PT ALLOY; CURIE TEMPERATURE; COAGULATION NECROSIS;

D O I：

10.1007/BF00146877

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An implant heating system using a ferromagnetic implant with low Curie temperature has been developed for treating human brain tumors. Safe and repeated hyperthermia was possible over periods averaging ten weeks in 23 out of 25 patients with malignant brain tumors without development of major side effects. Evaluation of the effects of this new treatment is still preliminary. Overall response rate was 34.8%. However, five of thirteen cases of malignant glioma and two of five cases of brain metastasis were responded well to interstitial hyperthermia given with or without irradiation. Pathological findings common to the treated tumors were circumscribed, ellipsoid shape of coagulation necrosis around the implant. Degeneration of tumor cells, hemorrhage, vascular stasis and thrombosis were found adjacent to the necrosis. In the future, a combination of interstitial hyperthermia with brachytherapy and chemotherapy may offer improved local control of brain tumor.

引用

页码：153 / 163

页数：11

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