HUMAN OVARIAN-CANCER CELL-LINES RESISTANT TO CISPLATIN, DOXORUBICIN, AND L-PHENYLALANINE MUSTARD ARE SENSITIVE TO DELTA-7-PROSTAGLANDIN A1 AND DELTA-12-PROSTAGLANDIN J2

被引:33
作者
SASAKI, H
TAKADA, K
TERASHIMA, Y
EKIMOTO, H
TAKAHASHI, K
TSURUO, T
FUKUSHIMA, M
机构
[1] NIPPON KAYAKU CO LTD, KITA KU, TOKYO 115, JAPAN
[2] UNIV TOKYO, INST APPL MICROBIOL, BUNKYO KU, TOKYO 113, JAPAN
[3] AICHI CANC CTR, DEPT INTERNAL MED, CHIKUSA KU, NAGOYA, AICHI 464, JAPAN
关键词
D O I
10.1016/0090-8258(91)90251-Y
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The antitumor activity of Δ7-prostaglandin A1 (Δ7-PGA1) or Δ12-prostaglandin J2 (Δ7-PGJ2) on human ovarian cancer cell lines resistant to cisplatin (CDDP), doxorubicin (ADR), and l-phenylalanine mustard (1-PAM) was studied in vitro. A2780AD, A2780 (parent cells of A2780AD), 2008DDP, and 2008 cells (parent cells of 2008DDP) were used. The antitumor activities of the drugs were defined with 50% inhibitory concentration (IC50) estimated from growth inhibition curves, which were obtained by an indirect colorimetric method. Drug-resistance ratios obtained from IC50 values, by comparing A2780AD and A2780 cells, were 62.5 for ADR, 4.6 for CDDP, 4.9 for 1-PAM, 1.5 for Δ7-PGA1, and 1.8 for Δ7-PGJ2. Those obtained by comparing 2008DDP and 2008 cells were 1.1 for ADR, 16.0 for CDDP, 2.9 for 1-PAM, 2.3 for Δ7-PGA1, and 3.2 for Δ7-PGJ2. Thus some human ovarian cancer cells resistant to ADR, CDDP, and 1-PAM remain sensitive to antitumor PGs. © 1991.
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页码:36 / 40
页数:5
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