LOW-DOSE ISRADIPINE ONCE DAILY EFFECTIVELY CONTROLS 24-H BLOOD-PRESSURE IN ESSENTIAL-HYPERTENSION

被引：17

作者：

DIEMONT, WL ^{[1
]}

STEGEMAN, CJ ^{[1
]}

BEEKMAN, J ^{[1
]}

SIEGERS, AMJ ^{[1
]}

HAGELS, G ^{[1
]}

DEBRUIJN, JHB ^{[1
]}

机构：

[1] MED SPECTRUM TWENTE,DEPT INTERNAL MED,ARIENSPLEIN 1,7511 JX ENSCHEDE,NETHERLANDS

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 02期

关键词：

ESSENTIAL HYPERTENSION; ISRADIPINE; 24-H BLOOD PRESSURE; CALCIUM ANTAGONIST;

D O I：

10.1093/ajh/4.2.163S

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

In one study of 10 patients with mild-to-moderate hypertension, equivalent total daily doses (13 +/- 2 mg) of isradipine given twice daily and a modified-release formulation of isradipine (isradipine MR) given once daily were found to control adequately 24 h ambulatory blood pressure compared with placebo (P < .001 for each upsilon placebo). In another study of 22 patients with essential hypertension, 5 and 10 mg isradipine MR once daily has been shown to reduce the average 24 h blood pressure by 11 +/- 1/6 +/- 1 mm Hg (P < .001) and 13 +/- 2/9 +/- 1 mm Hg (P < .001), respectively, compared with placebo. There was no loss of efficacy with isradipine MR during the 24 h observation period with either dose. In conclusion, low-dose isradipine MR once daily is an effective first-line treatment in essential hypertension.

引用

页码：S163 / S167

页数：5

共 6 条

[1]

Sundstedt C.D., Ruegg P.C., Keller A., Waite R., A multicenterevaluation of the safety, tolerability, and efficacy of isra- dipine in the treatment of essential hypertension, Am J Med, 86, pp. 98-102, (1989)

[2]

Dahlof B., Hemodynamic response, safety, and efficacy ofisradipine in the treatment of essential hypertension, Am J Med, 86, pp. 19-26, (1989)

[3]

Mazer N., Abisch E., Gfeller J.C., Et al., Intragastric behaviorand absorption kinetics of normal and 'floating' modified-release capsule of isradipine under fasted and fed conditions, J Pharm Sci, 77, pp. 647-657, (1988)

[4]

Vermeulen A., Wester A., Willemse P., Et al., Comparisonof isradipine and diltiazem in the treatment of essentialhypertension, Am J Med, pp. 42-45, (1988)

[5]

Meijer J.L., Ardesch H.G., Van Rooyen J.C., De Bruijn J., Low-dose captopril twice daily lowers blood pressurewithout disturbance of the normal circadian rhythm, Postgrad Med J, 62, pp. 101-105, (1986)

[6]

Kirkendall W.M., Comparative assessment of first-line agents for treatment of hypertension, Am J Med, 84, pp. 32-41, (1988)

← 1 →