IS THE COILED BODY INVOLVED IN NUCLEOLAR FUNCTIONS

被引：75

作者：

MALATESTA, M

ZANCANARO, C

MARTIN, TE

CHAN, EKL

AMALRIC, F

LUHRMANN, R

VOGEL, P

FAKAN, S

机构：

[1] UNIV LAUSANNE, CTR ELECTRON MICROSCOPY, CH-1005 LAUSANNE, SWITZERLAND

[2] UNIV VERONA, INST HUMAN ANAT & HISTOL, I-37134 VERONA, ITALY

[3] UNIV CHICAGO, DEPT MOLEC GENET & CELL BIOL, CHICAGO, IL 60637 USA

[4] SCRIPPS RES INST, DEPT MOLEC & EXPTL MED, LA JOLLA, CA 92037 USA

[5] CTR RECH BIOCHIM & GENET CELLULAIRE, F-31062 TOULOUSE, FRANCE

[6] INST MOLEK BIOL & TUMORFORSCH, D-35037 MARBURG, GERMANY

[7] UNIV LAUSANNE, INST ZOOL & ANIM ECOL, CH-1015 LAUSANNE, SWITZERLAND

来源：

EXPERIMENTAL CELL RESEARCH | 1994年 / 211卷 / 02期

关键词：

D O I：

10.1006/excr.1994.1106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Coiled bodies (CBs) are structural constituents observed in nuclei of most eukaryotic cells. They usually occur in the nucleoplasm as well as in contact with the nucleolar surface. In this work we studied the hepatocyte nuclei of hibernating dormice in order to investigate possible modifications of CBs along the seasonal cycle. CBs were abundant during hibernation and rapidly disappeared upon arousal from hibernation. Moreover, CBs were frequently found to be integrated into the nucleolar body. Immunocytochemical analyses showed that CBs contain nucleoplasmic as well as nucleolar RNA-processing factors, suggesting an ''ambiguous'' role for this organelle in the nuclear functions. (C) 1994 Academic Press, Inc.

引用

页码：415 / 419

页数：5

共 31 条

[1] HUMAN AUTOANTIBODY TO A NOVEL PROTEIN OF THE NUCLEAR COILED BODY - IMMUNOLOGICAL CHARACTERIZATION AND CDNA CLONING OF P80-COILIN [J].