RISK OF HEPATITIS-C SEROCONVERSION AFTER OCCUPATIONAL EXPOSURES IN HEALTH-CARE WORKERS

被引：138

作者：

PURO, V

PETROSILLO, N

IPPOLITO, G

ALOISI, MS

ANGARANO, G

ARICI, C

BACCARO, C

BIANCIARDI, L

BONAVENTURA, ME

BONAZZI, L

CAROSI, G

CATTELAN, AM

CHIODERA, A

CORRADI, MP

CRISTINI, G

DAGLIO, M

DECARLI, G

DEGENNARO, M

DESPERATI, M

DINARDO, V

FRANCAVILLA, E

FRANCESCONI, M

GAVIOLI, G

GIAMPEROLI, A

MIGLIORI, M

MILINI, P

MONTI, A

NELLI, M

ORLANDO, G

PIETROBON, F

PIRAZZINI, MC

RAINERI, G

RANCHINO, M

RAVA, L

REBORA, M

ROMANO, P

SALVI, A

SIGHINOLFI, L

SOMMELLA, L

SUTER, F

TANGENTI, M

TRAINA, C

VAGLIA, A

VLACOS, D

机构：

[1] Centro di Riferimento AIDS, L. Spallanzani Hospital, Rome

来源：

AMERICAN JOURNAL OF INFECTION CONTROL | 1995年 / 23卷 / 05期

关键词：

D O I：

10.1016/0196-6553(95)90056-X

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: To determine the incidence of hepatitis C virus (HCV) seroconversion, health care workers reporting an occupational exposure with blood or other risk-prone body materials from a patient known to be seropositive for HCV antibody were enrolled. Methods: HCV seroconversion within 6 months of a reported exposure was assessed by second-generation enzyme immunoassay and immunoblot assay. Results: From January 1992 through December 1993, 331 (51%) hollow-bore needlesticks, 105 (16.5%) suture needle or sharp object injuries, 85 (13%) mucous membrane contaminations, and 125 (19.5%) skin contaminations were reported. Four HCV seroconversions were observed after hollow-bore needlesticks (1.2%; 95% CI 0.3% to 3.0%); no seroconversions occurred after other routes of exposure. Blood-filled needlesticks and source patient coinfection with HIV appeared to be associated with a higher risk of seroconversion. Conclusions: The risk of HCV seroconversion after occupational exposure appears to be low but is not negligible. Aggressive implementation of universal precautions is important for preventing risk-prone exposure, but safer devices are also needed.

引用

页码：273 / 277

页数：5

共 25 条

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