MITOCHONDRIAL TOXICITY - NEW ADVERSE DRUG EFFECTS

[1] EFFECT OF FIALURIDINE ON REPLICATION OF MITOCHONDRIAL-DNA IN CEM CELLS AND IN HUMAN HEPATOBLASTOMA CELLS IN CULTURE [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (09) : 1997 - 2002

[2] CELLULAR AND MOLECULE EVENTS LEADING TO MITOCHONDRIAL TOXICITY OF 1-(2-DEOXY-2-FLUORO-1-BETA-D-ARABINOFURANOSYL)-5-LODOURACIL IN HUMAN LIVER-CELLS [J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (02) : 555 - 563

[3] DIENSTAG JL, IN PRESS N ENGL J ME

[4] MAMMALIAN DNA POLYMERASE-ALPHA, POLYMERASE-BETA, POLYMERASE-GAMMA, POLYMERASE-DELTA, AND POLYMERASE-EPSILON INCORPORATE FIALURIDINE (FIAU) MONOPHOSPHATE INTO DNA AND ARE INHIBITED COMPETITIVELY BY FIAU TRIPHOSPHATE [J]. BIOCHEMISTRY, 1994, 33 (48) : 14620 - 14624

[5] HEPATIC-FAILURE AND LACTIC-ACIDOSIS DUE TO FIALURIDINE (FIAU), AN INVESTIGATIONAL NUCLEOSIDE ANALOG FOR CHRONIC HEPATITIS-B [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (17) : 1099 - 1105

[6] A RANDOMIZED, CONTROLLED TRIAL OF INTERFERON ALFA-2B ALONE AND AFTER PREDNISONE WITHDRAWAL FOR THE TREATMENT OF CHRONIC HEPATITIS-B [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (05) : 295 - 301

[7] A PHASE I/II STUDY OF 2'-DEOXY-3'-THIACYTIDINE (LAMIVUDINE) IN PATIENTS WITH ADVANCED HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (06) : 1438 - 1447

[8] FIALURIDINE ACCUMULATES IN DNA OF DOGS, MONKEYS, AND RATS FOLLOWING LONG-TERM ORAL-ADMINISTRATION [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) : 12003 - 12007

[9] Robinson W. S., 1995, PRINCIPLES PRACTICE, P1406

[10] STEVENSON W, 1995, TRANSPLANT P, V27, P1219

[1] EFFECT OF FIALURIDINE ON REPLICATION OF MITOCHONDRIAL-DNA IN CEM CELLS AND IN HUMAN HEPATOBLASTOMA CELLS IN CULTURE [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (09) : 1997 - 2002

[2] CELLULAR AND MOLECULE EVENTS LEADING TO MITOCHONDRIAL TOXICITY OF 1-(2-DEOXY-2-FLUORO-1-BETA-D-ARABINOFURANOSYL)-5-LODOURACIL IN HUMAN LIVER-CELLS [J]. JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (02) : 555 - 563

[3] DIENSTAG JL, IN PRESS N ENGL J ME

[4] MAMMALIAN DNA POLYMERASE-ALPHA, POLYMERASE-BETA, POLYMERASE-GAMMA, POLYMERASE-DELTA, AND POLYMERASE-EPSILON INCORPORATE FIALURIDINE (FIAU) MONOPHOSPHATE INTO DNA AND ARE INHIBITED COMPETITIVELY BY FIAU TRIPHOSPHATE [J]. BIOCHEMISTRY, 1994, 33 (48) : 14620 - 14624

[5] HEPATIC-FAILURE AND LACTIC-ACIDOSIS DUE TO FIALURIDINE (FIAU), AN INVESTIGATIONAL NUCLEOSIDE ANALOG FOR CHRONIC HEPATITIS-B [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (17) : 1099 - 1105

[6] A RANDOMIZED, CONTROLLED TRIAL OF INTERFERON ALFA-2B ALONE AND AFTER PREDNISONE WITHDRAWAL FOR THE TREATMENT OF CHRONIC HEPATITIS-B [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (05) : 295 - 301

[7] A PHASE I/II STUDY OF 2'-DEOXY-3'-THIACYTIDINE (LAMIVUDINE) IN PATIENTS WITH ADVANCED HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J]. JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (06) : 1438 - 1447

[8] FIALURIDINE ACCUMULATES IN DNA OF DOGS, MONKEYS, AND RATS FOLLOWING LONG-TERM ORAL-ADMINISTRATION [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (25) : 12003 - 12007

[9] Robinson W. S., 1995, PRINCIPLES PRACTICE, P1406

[10] STEVENSON W, 1995, TRANSPLANT P, V27, P1219