A TWIN STUDY OF AGE-RELATED MACULAR DEGENERATION

被引：127

作者：

MEYERS, SM ^{[1
]}

GREENE, T ^{[1
]}

GUTMAN, FA ^{[1
]}

机构：

[1] CLEVELAND CLIN FDN,DEPT BIOSTAT & EPIDEMIOL,CLEVELAND,OH 44195

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 1995年 / 120卷 / 06期

关键词：

D O I：

10.1016/S0002-9394(14)72729-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE: To determine the importance of genetic factors in age related macular degeneration by using a twin study to compare the concordance of age-related macular degeneration in monozygotic and dizygotic twin pairs. METHODS: We prospectively examined 134 consecutive twin pairs and two triplet sets for age-related macular degeneration. The zygosity was determined by genetic laboratory tests. RESULTS: The concordance of age-related macular degeneration was 100% (25 of 25) in monozygotic and 42% (five of 12) in dizygotic twin pairs. The other twins or triplets had no macular changes of age-related macular degeneration. CONCLUSIONS: The statistically significant higher concordance of age related macular degeneration in monozygotic than in dizygotic twin pairs and the clinical heterogeneity of age-related macular degeneration strongly suggest the importance of genetic and nongenetic factors, respectively, in age-related macular degeneration.

引用

页码：757 / 766

页数：10

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