THE FUSION OF TEL AND ABL IN HUMAN ACUTE LYMPHOBLASTIC-LEUKEMIA IS A RARE EVENT

被引：42

作者：

JANSSEN, JWG

RIDGE, SA

PAPADOPOULOS, P

COTTER, F

LUDWIG, WD

FONATSCH, C

RIEDER, H

OSTERTAG, W

BARTRAM, CR

WIEDEMANN, LM

机构：

[1] INST CANC RES,CHESTER BEATTY LABS,LEUKAEMIA RES FUND CTR,LONDON SW3 6JB,ENGLAND

[2] UNIV ULM,DEPT PAEDIAT 2,MOLEC BIOL SECT,W-7900 ULM,GERMANY

[3] UNIV HAMBURG,HEINRICH PETTE INST EXPTL VIROL & IMMUNOL,W-2000 HAMBURG,GERMANY

[4] INST CHILD HLTH,LONDON,ENGLAND

[5] FREE UNIV BERLIN,ROBERT ROSSLE KLIN,DEPT MED ONCOL & APPL MOLEC BIOL,W-1000 BERLIN,GERMANY

[6] UNIV LUBECK,INST HUMAN GENET,W-2400 LUBECK,GERMANY

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 90卷 / 01期

关键词：

ALL; GENE FUSION; RT-PCR;

D O I：

10.1111/j.1365-2141.1995.tb03407.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have recently identified a common ALL patient which harboured a chromosomal fusion between the TEL gene on chromosome 12 and the ABL gene on chromosome 9. We designed an RT-PCR assay to screen 186 adult ALL and 30 childhood ALL patients for this novel translocation. We were unable to identify any additional cases with a TEL/ABL fusion product.

引用

页码：222 / 224

页数：3

共 12 条

[1]

BUIJS A, 1995, IN PRESS ONCOGENE

[2] FUSION OF PDGF RECEPTOR-BETA TO A NOVEL ETS-LIKE GENE, TEL, IN CHRONIC MYELOMONOCYTIC LEUKEMIA WITH T(512) CHROMOSOMAL TRANSLOCATION [J].