HOW DO FISH OILS AFFECT VASCULAR FUNCTIONS

被引：55

作者：

CHIN, JPF ^{[1
]}

DART, AM ^{[1
]}

机构：

[1] BAKER MED RES INST,PRAHRAN,VIC 3181,AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1995年 / 22卷 / 02期

关键词：

FISH OILS; NITRIC OXIDE; PROSTANOIDS; VASCULAR FUNCTION; VASCULAR REACTIVITY;

D O I：

10.1111/j.1440-1681.1995.tb01959.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. This is a review on the mechanisms by which fish oils affect vascular function and how such changes contribute to their documented cardioprotective effects. 2. Evidence that fish oils depress vascular responses to contractile agents will be examined. It is concluded that this effect of fish oils is mediated predominantly by alterations in prostanoid profile. 3. Effects of fish oils on arterial relaxation are discussed with particular emphasis on endothelium dependent relaxation. It is suggested that the functional impairment of endothelium dependent relaxation documented in a number of cardiovascular disease states can be reversed by dietary fish oils. 4. In addition, possible effects of fish oils on growth factors, inositol trisphosphate and lipid metabolism, the sympathetic nervous system, theological and membrane properties and inducible nitric oxide are reviewed.

引用

页码：71 / 81

页数：11

共 81 条

[1] DIFFERENTIAL-EFFECTS OF DIETARY FISH OIL ON MYOCARDIAL PROSTAGLANDIN-I2 AND THROMBOXANE-A2 PRODUCTION [J].