ANALYSIS OF THE SERUM IGE LEVELS IN NON-IMMUNIZED RATS OF VARIOUS STRAINS BY A RADIOIMMUNOASSAY

被引：62

作者：

KARLSSON, T ^{[1
]}

ELLERSON, JR ^{[1
]}

DAHLBOM, I ^{[1
]}

BENNICH, H ^{[1
]}

机构：

[1] UNIV UPPSALA, CTR BIOMED, INST MED & PHYSIOL CHEM, S-75123 UPPSALA, SWEDEN

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1979年 / 9卷 / 03期

关键词：

D O I：

10.1111/j.1365-3083.1979.tb02725.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An assay, the paper radioimmunosorbent test (PRIST) for the measurement of total serum IgE in the rat, that allows the measurement of IgE down to a level of 0.25 ng/ml, is described. With this assay it has been demonstrated that significant differences exist in normal serum IgE levels in non‐immunized rats. These differences are strain‐dependent, and strains may be classified as to low (<50 ng/ml), medium (50–300 ng/ml) or high (>300 ng/ml) serum levels. The serum IgE level is not sex‐dependent. Environmental factors have a pronounced influence, optimal housing conditions resulting in low and stable levels while suboptimal conditions result in high levels with great fluctuations. Hybridization experiments suggest a multigenic control, with low IgE strains having a dominating suppressor effect. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：217 / 228

页数：12

共 20 条

[1] 3 CLASSES AND 4 (SUB)CLASSES OF RAT IMMUNOGLOBULINS - IGM, IGA, IGE AND IGG1, IGG2A, IGG2B, IGG2C
BAZIN, H
BECKERS, A
QUERINJE.P
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1974, 4 (01) : 44 - 48
[2] Bennich H, 1971, Adv Immunol, V13, P1
[3] BENNICH H, 1976, MOL BIOL ASPECTS ACU, P175
[4] BENNICH HH, 1978, IMMEDIATE HYPERSENSI, P1
[5] CARSON D, 1975, J IMMUNOL, V114, P521
[6] CARSON D, 1975, J IMMUNOL, V115, P561
[7] NEW AND SIMPLE RADIOIMMUNOASSAY METHOD FOR DETERMINATION OF IGE
CESKA, M
LUNDKVIST, U
[J]. IMMUNOCHEMISTRY, 1972, 9 (10): : 1021 - +
[8] Cuatrecasas P., 1971, METHOD ENZYMOL, V22, P345
[9] ELLERSON JR, 1978, 25TH PROT BIOL FLUID, P739
[10] ELLERSON JR, UNPUBLISHED

← 1 2 →