RELIABLE ROUTINE METHOD FOR THE DETERMINATION OF PLASMA AMITRIPTYLINE AND NORTRIPTYLINE BY GAS-CHROMATOGRAPHY

被引：27

作者：

BURCH, JE ^{[1
]}

RADDATS, MA ^{[1
]}

THOMPSON, SG ^{[1
]}

机构：

[1] HIGH ROYDS HOSP,REG METAB RES UNIT,MENSTON,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 162卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0378-4347(00)81521-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A gas chromatographic method has been developed for the determination of amitriptyline and nortriptyline in plasma. OV-17 is used in a 1 m long packed column, with a flame ionization detector and an electronic integrator. Five internal standards are added. The base-specific extraction procedure and the method of calibrating the chromatograph are described in detail. The accuracy, precision and reliability of the method are demonstrated by the results of nearly 700 determinations of each drug, at concentrations ranging from 5 to 400 ng/ml in the plasma. An interlaboratory comparison with a double radioactive isotope derivative assay for nortriptyline has also shown satisfactory agreement. © 1979.

引用

页码：351 / 366

页数：16

共 30 条

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