MULTIION SENSING SYSTEM BASED ON GLASS-ENCAPSULATED PH-ISFETS AND A PSEUDO-REFET

被引:36
作者
VANDENVLEKKERT, HH [1 ]
DEROOIJ, NF [1 ]
VANDENBERG, A [1 ]
GRISEL, A [1 ]
机构
[1] CTR SUISSE ELECTR & MICROTECH SA,CH-2007 NEUCHATEL,SWITZERLAND
关键词
D O I
10.1016/0925-4005(90)80237-T
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Since the introduction of CHEMFETs much attention has been paid to the development of multi-ion sensors especially for extra-corporeal continuous patient monitoring. Most of the systems use different ionophores, suspended in inert matrices on top of the gate insulator, to provide multi-ion sensitivity. A system is developed whereby glass is used to encapsulate the individual sensors thereby providing not only an excellent encapsulation but also a means to immobilize hydrogels and membranes. To avoid the problem of the reference electrode a pH-sensitive ISFET with a retarded pH response was developed, thereby creating the possibility to operate this ISFET as an ion-insensitive FET over short periods of time (pseudo-REFET). A multi-ion sensor, consisting of a pH-sensitive, a potassium-sensitive and a calcium-sensitive ISFET together with a pseudo-REFET, is developed. It is shown that in the differential measurement set-up, the system exhibits a high precision in combination with a high sample frequency. Furthermore the modelization of the pseudo-REFET permits the estimation of diffusion coefficient of hydrogen ions in different hydrogels. © 1990.
引用
收藏
页码:395 / 400
页数:6
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