MODE OF ACTION OF GR69153, A NOVEL CATECHOL-SUBSTITUTED CEPHALOSPORIN, AND ITS INTERACTION WITH THE TONB-DEPENDENT IRON TRANSPORT-SYSTEM

被引：55

作者：

SILLEY, P ^{[1
]}

GRIFFITHS, JW ^{[1
]}

MONSEY, D ^{[1
]}

HARRIS, AM ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DEPT CHEMOTHERAPY,DIV MICROBIOL,GREENFORD RD,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 09期

关键词：

D O I：

10.1128/AAC.34.9.1806

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

GR69153 is a novel cephalosporin incorporating a catechol-substituted 7-aminothiazolyl-oxime. The antibiotic is actively transported into gram-negative cells via iron-regulated outer membrane proteins regulated by the tonB product. This transport enhances bactericidal activity most significantly at low concentrations, essentially removing the permeability barrier for antibiotic uptake.

引用

页码：1806 / 1808

页数：3

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