INHIBITION OF ALLERGIC FOOTPAD INFLAMMATION BY ANTI-RHEUMATIC DRUG D-PENICILLAMINE

被引：13

作者：

TSURUFUJI, S

OHUCHI, K

ISHIGURO, M

MIURA, M

机构：

[1] Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai 980, Aramaki, Aoba

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1979年 / 2卷 / 03期

关键词：

anti-allergic; azobenzenearsonate-acetyl bovine serum albumin; D-penicillamine; inflammation; mouse footpad test;

D O I：

10.1248/bpb1978.2.187

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An allergic footpad inflammation of mice was induced by using azobenzenearsonateacetyl bovine serum albumin conjugate as an antigen. Sensitization was made with the aid of Freund's complete adjuvant and the allergic reaction was elicited by using an emulsion consisting of Freund's incomplete adjuvant and 0.9% NaCl solution as a carrier of the challenging antigen. Allergic footpad swelling reached a maximum 24 hr after the challenge dose. D-Penicillamine, an anti-rheumatic drug, exerted a strong inhibitory effect on the allergic process, if animals were treated with this drug for 21 days at a dose of 600 mg/kg/day. © 1979, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：187 / 189

页数：3

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