SIMULTANEOUS MEASUREMENT OF PLASMA-CATECHOLAMINE (NOREPINEPHRINE, EPINEPHRINE, AND DOPAMINE) AND FREE N-METHYL DOPAMINE (EPININE) LEVELS, BY HPLC WITH ELECTROCHEMICAL DETECTION

被引:29
作者
MUSSO, NR
VERGASSOLA, C
PENDE, A
LOTTI, G
机构
[1] Cattedra di Patologia Speciale Medica R - ISMI Università di Genova, 16132, Genoa, Viale Benedetto XV
来源
JOURNAL OF LIQUID CHROMATOGRAPHY | 1990年 / 13卷 / 11期
关键词
D O I
10.1080/01483919008049025
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Epinine is the active moiety of ibopamine, a cardiovascular prodrug used in congestive heart failure. This catecholic compound shows dopaminergic and adrenergic properties. Moreover the drug seems to affect plasma catecholamine levels in patients with heart failure. Here we present a method developed for the simultaneous determination of epinine and catecholamine plasma levels. Free epinine and catecholamines were extracted from human venous plasma via an alumina adsorption procedure. The extracts underwent an ion-pair reversed-phase HPLC separation with three-electrode coulometry. Quantitation was made by an internal standard method. Coefficients of variation were < 9 %. The validity was assessed as the peak. © 1990, Taylor & Francis Group, LLC. All rights reserved.
引用
收藏
页码:2217 / 2228
页数:12
相关论文
共 6 条
[1]   ANALYSIS OF EPININE AND ITS METABOLITES IN MAN AFTER ORAL-ADMINISTRATION OF ITS PRO-DRUG IBOPAMINE USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION [J].
GIFFORD, R ;
RANDOLPH, WC ;
HEINEMAN, FC ;
ZIEMNIAK, JA .
JOURNAL OF CHROMATOGRAPHY, 1986, 381 (01) :83-93
[2]   IBOPAMINE - A PRELIMINARY REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES AND THERAPEUTIC EFFICACY [J].
HENWOOD, JM ;
TODD, PA .
DRUGS, 1988, 36 (01) :11-31
[3]  
MUSSO NR, 1989, CLIN CHEM, V35, P1975
[4]  
NAKANO T, 1986, ARZNEIMITTEL-FORSCH, V36-2, P1829
[5]   EFFECTS OF LONG-TERM THERAPY WITH ORAL IBOPAMINE ON RESTING HEMODYNAMICS AND EXERCISE CAPACITY IN PATIENTS WITH HEART-FAILURE - RELATIONSHIP TO THE GENERATION OF N-METHYLDOPAMINE AND TO PLASMA NOREPINEPHRINE LEVELS [J].
RAJFER, SI ;
ROSSEN, JD ;
DOUGLAS, FL ;
GOLDBERG, LI ;
KARRISON, T .
CIRCULATION, 1986, 73 (04) :740-748
[6]   RAT RENAL EPINEPHRINE SYNTHESIS [J].
ZIEGLER, MG ;
KENNEDY, B ;
ELAYAN, H .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (04) :1130-1133