A VERSATILE SYNTHESIS OF STEREOSPECIFICALLY LABELED D-AMINO ACIDS AND RELATED ENZYME-INHIBITORS

被引：16

作者：

AXELSSON, BS ^{[1
]}

OTOOLE, KJ ^{[1
]}

SPENCER, PA ^{[1
]}

YOUNG, DW ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 16期

关键词：

D O I：

10.1039/c39910001085

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stereospecifically deuteriated isoserines 4, formed from enzymically prepared 3-deuteriated malic acids 2 (X = OH) by Curtius rearrangement, have been converted to the deuteriated aziridines 7 and 9 which, on ring-opening and deprotection, yielded samples of the amino acids D-serine and D-cystine and the enzyme inhibitor-substrates D-beta-chloroalanine and D-serine O-sulphate which are labelled stereospecifically at C-3 with deuterium.

引用

页码：1085 / 1086

页数：2

共 19 条

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