BEHAVIORAL-FACTORS IN STRESS-INDUCED IMMUNOMODULATION

被引：20

作者：

SANDI, C ^{[1
]}

BORRELL, J ^{[1
]}

GUAZA, C ^{[1
]}

机构：

[1] CSIC,CAJAL INST,PSYCHOBIOL RES GRP,MADRID 6,SPAIN

来源：

BEHAVIOURAL BRAIN RESEARCH | 1992年 / 48卷 / 01期

关键词：

INDIVIDUAL DIFFERENCES; STRESS; NOVELTY; NEUROIMMUNOMODULATION; RAT;

D O I：

10.1016/S0166-4328(05)80144-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Individual differences in the exploratory response to novelty were found to be related with the vulnerability to develop stress-induced immunological alterations. We studied the effect of exposure to inescapable shock on antibody formation against sheep red blood cells (SRBC) in rats selected according to their locomotor activity in a novel situation. Interestingly, antibody titers were only enhanced in shocked animals with the highest locomotor activity. These results emphasize the importance of taking into account individual differences for the study of the mechanisms involved in stress-induced immunomodulation, suggesting a behavioral procedure (novelty reactions) to deal with individual variability in the effects of stress on the immune system.

引用

页码：95 / 98

页数：4

共 20 条

[1] INTERACTIONS BETWEEN THE BRAIN AND THE IMMUNE-SYSTEM [J].