RELATION OF SMOKING AND ALCOHOL-CONSUMPTION TO INCIDENT ALZHEIMERS-DISEASE

被引：98

作者：

HEBERT, LE

SCHERR, PA

BECKETT, LA

FUNKENSTEIN, HH

ALBERT, MS

CHOWN, MJ

EVANS, DA

机构：

[1] RUSH PRESBYTERIAN ST LUKES MED CTR,CTR RES HLTH & AGING,1653 W CONGRESS PKWY,CHICAGO,IL 60612

[2] HARVARD UNIV,SCH PUBL HLTH,DEPT HLTH POLICY & MANAGEMENT,BOSTON,MA 02115

[3] CTR DIS CONTROL,NATL CTR CHRON DIS PREVENT & HLTH PROMOT,AGING BRANCH,ATLANTA,GA 30333

[4] BRIGHAM & WOMENS HOSP,DEPT MED,DIV NEUROL,BOSTON,MA 02115

[5] MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT,BOSTON,MA 02114

[6] BRIGHAM & WOMENS HOSP,DEPT MED,CHANNING LAB,BOSTON,MA 02115

[7] HARVARD UNIV,SCH MED,DEPT PSYCHIAT,BOSTON,MA 02115

[8] HARVARD UNIV,SCH PUBL HLTH,DEPT BIOSTAT,BOSTON,MA 02115

[9] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

[10] MASSACHUSETTS GEN HOSP,DEPT NEUROL,BOSTON,MA 02114

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 1992年 / 135卷 / 04期

关键词：

AGED; ALCOHOL DRINKING; ALZHEIMERS DISEASE; EPIDEMIOLOGY; INCIDENCE; RISK FACTORS; SMOKING;

D O I：

10.1093/oxfordjournals.aje.a116296

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The authors examined the effects of smoking and alcohol use in a prospective community-based study of incident Alzheimer's disease. Two in-home interviews of the total elderly population of East Boston, Massachusetts, conducted in 1982 and 1985 were used to sample individuals for clinical evaluation for Alzheimer's disease. A total of 513 persons underwent detailed clinical evaluation including neurologic, neuropsychologic, and psychiatric evaluation to diagnose Alzheimer's disease. In weighted logistic regression controlled for age, sex, and education, the estimated odds ratio of Alzheimer's disease was 0.7 (95% confidence interval 0.3-1.4) for ever smokers compared with never smokers. For 40 pack-years of smoking, the odds ratio of Alzheimer's disease was 0.8 (95% confidence interval 0.6-1.1). Consumption of 1 oz (30 ml) of alcohol per day was associated with an odds ratio of 1.1 (95% confidence interval 0.8-1.5). These results suggest that recent mild-to-moderate consumption of alcohol is not substantially related to incidence of Alzheimer's disease and that smoking does not increase risk of the disease.

引用

页码：347 / 355

页数：9

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