CONTINUUM MODELS OF PLATELET-AGGREGATION - FORMULATION AND MECHANICAL-PROPERTIES

被引:106
作者
FOGELSON, AL [1 ]
机构
[1] NYU,COURANT INST MATH SCI,NEW YORK,NY 10012
基金
美国国家科学基金会;
关键词
PLATELET AGGREGATION; CONTINUUM MODELS; INCOMPRESSIBLE VISCOUS FLOW; CONVECTION-DIFFUSION-REACTION EQUATIONS; ELASTICITY; COMPUTATIONAL FLUID DYNAMICS;
D O I
10.1137/0152064
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
Platelet aggregation is an important component of the blood's clotting response, and is associated as well with many forms of cardiovascular disease. A new class of continuum models of platelet aggregation is presented. The models describe interactions among a viscous, incompressible fluid and populations of nonactivated (nonsticky) and activated (sticky) platelets suspended in this fluid. Cohesion between activated platelets can profoundly influence the motion of the suspending fluid. A platelet-activating chemical triggers a platelet's transition from nonactivated to activated status, and induces the secretion of more of the same chemical. Investigation of the mechanical properties of the fluid-platelet system in the absence of new activation shows that platelet cohesion can generate extra pressure and extra viscous and elastic stresses. The last is sufficient to maintain the integrity of an aggregate that is subject to substantial external stress.
引用
收藏
页码:1089 / 1110
页数:22
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