THE GASTRIC ANTIULCER EFFECTS OF THE LEAVES OF THE NEEM TREE

被引：47

作者：

GARG, GP

NIGAM, SK

OGLE, CW

机构：

[1] UNIV HONG KONG,FAC MED,DEPT PHARMACOL,5 SASSOON RD,HONG KONG,HONG KONG

[2] NATL BOT RES INST,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

PLANTA MEDICA | 1993年 / 59卷 / 03期

关键词：

NEEM TREE; MELIA-AZADIRACHTA; AZADI-RACHTA INDICA; ANTIULCER ACTIVITY;

D O I：

10.1055/s-2006-959654

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The antiulcer effect of aqueous extracts of the leaves of the neem tree was investigated in rats exposed to 2-h cold-restraint stress or given ethanol orally for 1 h. Extracts were administered in doses of 10, 40, or 160 mg leaf/kg body weight, either as single- or five-dose pretreatment regimens. Neem dose-dependently reduced gastric ulcer severity in rats subjected to stress and also decreased ethanol provoked gastric mucosal damage. The extract appeared to prevent mast cell degranulation and to increase the amount of adherent gastric mucus in stressed animals. These effects may explain, at least in part, the mode of the antiulcer action of neem.

引用

页码：215 / 217

页数：3

共 14 条

[1]

Armitage P, 1987, STAT METHODS MED RES, P93

[2] CHOLINERGIC-MEDIATED GASTRIC MAST-CELL DEGRANULATION WITH SUBSEQUENT HISTAMINE H-1-RECEPTOR AND H-2-RECEPTOR ACTIVATION IN STRESS ULCERATION IN RATS [J].