DETERMINATION OF BIS(AMIDINOHYDRAZONES) BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY

被引：11

作者：

LUKKARI, P

JUMPPANEN, J

JINNO, K

ELO, H

RIEKKOLA, ML

机构：

[1] UNIV HELSINKI,DEPT CHEM,DIV ANALYT CHEM,VUORIKATU 20,SF-00100 HELSINKI 10,FINLAND

[2] TOYOHASHI UNIV TECHNOL,TOYOHASHI,AICHI 440,JAPAN

[3] UNIV HELSINKI,DEPT PHARM,DIV CHEM,SF-00170 HELSINKI 17,FINLAND

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1992年 / 10卷 / 08期

关键词：

BIS(AMIDINOHYDRAZONES); BIS(GUANYLHYDRAZONES); MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY; CTAB SURFACTANT;

D O I：

10.1016/0731-7085(92)80081-W

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A micellar electrokinetic capillary chromatography method was developed for the separation and determination of aliphatic congeners of bis(amidinohydrazones) in standard solution. Eight bis(amidinohydrazones) could be determined in less than 15 min at an applied voltage of 22 kV, using 0.05 M sodium phosphate as buffer (pH 7.0) together with 1 mM N-cetyl-N.N,N-trimethylammonium bromide. Hydrostatic sample injection was employed. The method exhibited good repeatability and a linear range of 2.5-100 mug ml-1. A detection limit of 1 mug ml-1 was achieved. The method also allows the determination of bis(amidinohydrazones) in human serum samples.

引用

页码：561 / 565

页数：5

共 18 条

[1] HIGH-PERFORMANCE CAPILLARY ELECTROPHORETIC SEPARATION OF BASES, NUCLEOSIDES, AND OLIGONUCLEOTIDES - RETENTION MANIPULATION VIA MICELLAR SOLUTIONS AND METAL ADDITIVES [J].