LOW SERUM TRYPTOPHAN TO LARGE NEUTRAL AMINO-ACIDS RATIO IN IDIOPATHIC INFANTILE-AUTISM

被引：37

作者：

DEUFEMIA, P ^{[1
]}

FINOCCHIARO, R ^{[1
]}

CELLI, M ^{[1
]}

VIOZZI, L ^{[1
]}

MONTELEONE, D ^{[1
]}

GIARDINI, O ^{[1
]}

机构：

[1] CATHOLIC UNIV ROME,INST NEUROL,I-00100 ROME,ITALY

来源：

BIOMEDICINE & PHARMACOTHERAPY | 1995年 / 49卷 / 06期

关键词：

AMINO ACIDS; AUTISM; SEROTONIN;

D O I：

10.1016/0753-3322(96)82645-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The serum tryptophan to large neutral amino acids ratio (Try/LNAA) is considered a reliable marker of tryptophan availability for brain serotonin synthesis. A dysfunction of brain serotonergic activity has been postulated to exist in autistic disorder and supported by recent studies. On this basis, we determined the serum amino acids levels in 40 children with idiopathic infantile autism as well as in 46 control children. A significantly lower serum Try/LNAA ratio was observed in the autistic subjects compared to the normal controls. In 14 autistic children (35%) this ratio was 2 SD below the mean value obtained in the control group. These results suggest that a low brain tryptophan avalaibility due to a low serum Try/LNAA ratio could be one of the possible mechanisms involved in the alteration of serotonergic function in autism.

引用

页码：288 / 292

页数：5

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