MITOCHONDRIA HAVE FE(III) RECEPTORS

被引：22

作者：

WEAVER, J ^{[1
]}

ZHAN, H ^{[1
]}

POLLACK, S ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED,DIV HEMATOL,1300 MORRIS PK AVE,BRONX,NY 10461

来源：

BIOCHEMICAL JOURNAL | 1990年 / 265卷 / 02期

关键词：

D O I：

10.1042/bj2650415

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent work has provided new evidence that ATP is the major constituent of the low-M(r) iron pool in the reticulocyte. The interaction of the iron complex of ATP with mitochondria was investigated in the present experiments. When ATP-Fe3+ was incubated with mitochondria, Fe3+, free of ATP, bound with high affinity to Fe3+ receptors on the mitochondria. The binding was saturable and reversible. Iron which was complexed to PP(i), nitrilotriacetate, citrate, ADP and GTP also showed saturable binding to mitochondria; Fe3+ complexed to AMP bound non-specifically, as did Fe2+/ascorbate and Fe2+/dithionite.

引用

页码：415 / 419

页数：5

共 41 条

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