MOLECULAR CLONING AND NUCLEOTIDE-SEQUENCE OF THE HUMAN GROWTH-HORMONE STRUCTURAL GENE

被引：68

作者：

ROSKAM, WG

ROUGEON, F

机构：

[1] Unitè de Gè Gènètique Groupe, Biologie Molèculaire du Géne, ERA. C.N.R.S. No 201, Institut Pasteur, 75724, Paris, Cedex 15, 28, Rue du Docteur Roux

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 7卷 / 02期

关键词：

D O I：

10.1093/nar/7.2.305

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An almost complete cDNA copy of human growth hormone has been cloned and sequenced. The nucleotide sequence confirms the known protein sequence and predicts the sequence of a precursor region of 26 amino acids. We have compared the nucleotide sequence to that for the homologous proteins, rat growth hormone and human chorionic somatomammotropin (Seeburg et al. and Shine et al. , Nature 270, 486 (1977)). There appears to be evolutionary conservation of mRNA sequence features not related to protein structure. © 1979 Information Retrieval Limited.

引用

页码：305 / 320

页数：16

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