ISSUES OF RISK ASSESSMENT - LESSONS FROM THE USE AND ABUSE OF DRUGS DURING PREGNANCY

被引：25

作者：

HUTCHINGS, DE

机构：

[1] New York State Psychiatric Institute Department of Developmental Psychobiology, New York

来源：

NEUROTOXICOLOGY AND TERATOLOGY | 1990年 / 12卷 / 03期

关键词：

Animal models; Cannabis; Cocaine; Drug abuse; Neonatal withdrawal; Opioids; Pair-feeding; Pharmacokinetics; Phencyclidine; Prenatal; Risk assessment; Surrogate fostering;

D O I：

10.1016/0892-0362(90)90090-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Therapeutic uses and risks associated with the opioids, cannabis, cocaine, and phencyclidine are discussed as well as limitations of the developmental animal and clinical pediatric literature, especially with respect to problems of quantitative risk assessment. Human and animal developmental findings for methadone and cannabis are compared with respect to long-term behavioral effects with special emphasis on pharmacological and interpretive issues. It is suggested that neonatal withdrawal is the most serious neurobehavioral sequela associated with maternal use of opioid and other sedative-hypnotic compounds. Withdrawal phenomena are described and attempts to develop animal models are discussed. Methodological considerations including surrogate fostering, pair-feeding, and problems associated with the administration of compounds to lactating dams are discussed in the context of the adequacy of the EPA developmental neurotoxicology battery to characterize risk for abuse substances as well as the new NIDA medication compounds. © 1990.

引用

页码：183 / 189

页数：7

共 31 条

[1]

Abel E.L., 1986, HDB BEHAV TERATOLOGY, DOI [10.1007/978-1-4613-2189-7_12, DOI 10.1007/978-1-4613-2189-7_12]

[2] DELTA-9-TETRAHYDROCANNABINOL DURING PREGNANCY IN THE RAT .2. EFFECTS ON ONTOGENY OF LOCOMOTOR-ACTIVITY AND NIPPLE ATTACHMENT IN THE OFFSPRING [J].