DIRECT DERIVATIZATION OF SULFATE ESTERS FOR ANALYSIS BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：34

作者：

MURRAY, S

BAILLIE, TA

机构：

[1] Department of Clinical Pharmacology, Royal Postgraduate Medical School, London, W12 0HS, Ducane Road

[2] Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, California

来源：

BIOMEDICAL MASS SPECTROMETRY | 1979年 / 6卷 / 02期

关键词：

D O I：

10.1002/bms.1200060209

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Gas chromatography mass spectrometry has been used to study the reaction between a range of aromatic, alicyclic and aliphatic sulphate esters and three perfluoroacylating reagents, viz. trifluoroacetic, pentafluoropropionic and heptafluorobutyric anhydride. Aromatic sulphates were found to react readily, when treated with a 1:1 mixture of a perfluoroacid anhydride and dry ethyl acetate, to form the perfluoroester derivative of the parent phenol in quantitative yield. Non‐aromatic sulphates, on the other hand, gave a variety of products. A mechanism is proposed for the one‐step derivatization of aromatic sulphates and the potential of the procedure for the analysis of sulphate conjugates by mass spectrometry is discussed. Copyright © 1979 Heyden & Son Ltd

引用

页码：82 / 89

页数：8

共 24 条

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