ANTIPILI ANTIBODY AFFORDS PROTECTION AGAINST EXPERIMENTAL ASCENDING PYELONEPHRITIS

被引:99
作者
SILVERBLATT, FJ
COHEN, LS
机构
关键词
D O I
10.1172/JCI109458
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The ability of antipili antibody to prevent urinary tract infection was investigated in rats. One group of rats was immunized passively with rabbit antisera to purified pili and challenged by intravesicular inoculation of 5 x 107 heavily piliated Escherichia coli. Only 2 of 14 immunized animals developed cortical abscesses as compared to 13 of 15 control rats given normal rabbit serum (P=0.0001). The mean log titer of bacteria in the kidneys of the immunized rats was 0.85 vs. 6.08 in the controls (P<0.005). A second group was actively immunized with pili. 3 of 16 immunized animals became infected as compared to 10 of 15 controls (P=0.01). The mean log titers were 2.13 and 4.54, respectively (P<0.001). A third group was passively immunized and challenged with a strain that had different O, K, and H antigens but shared pili antigens. Abscesses occurred in 4 of 15 immunized animals as compared to 13 of 15 controls (P=0.001). The mean log titers were 2.37 and 5.63, respectively (P<0.005). These results indicate that antipili antibody protects rats against ascending urinary tract infection.
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页码:333 / 336
页数:4
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