THE EFFECT OF A NEW IMMUNOSUPPRESSIVE AGENT, FK-506, ON XENOGENEIC NEURAL TRANSPLANTATION IN RODENTS

被引：43

作者：

SAKAI, K

DATE, I

YOSHIMOTO, Y

ARISAWA, T

NAKASHIMA, H

FURUTA, T

ASARI, S

OHMOTO, T

机构：

[1] Department of Neurological Surgery, Okayama University Medical School, Okayama

来源：

BRAIN RESEARCH | 1991年 / 565卷 / 01期

关键词：

NEURAL TRANSPLANTATION; XENOGRAFT; FK-506; IMMUNOSUPPRESSION;

D O I：

10.1016/0006-8993(91)91750-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examines the effect of a novel immunosuppressive agent FK-506 (FK) on the survivability of embryonic (E14) rat ventral mesencephalic tissue after intracerebral grafting to the lateral ventricle of adult mice. The recipient mice were given FK in doses of 10 mg/kg or 1 mg/kg for 2 weeks postgrafting, at which time they were sacrificed and histologically processed except for one group of animals on the high dose (10 mg/kg). In this group most animals died from side effects of the drug during the following days. Only the mice receiving the high dose of FK displayed healthy grafts without signs of rejection.

引用

页码：167 / 170

页数：4

共 32 条

[1] UTILIZATION OF UNILATERAL AND BILATERAL STEREOTAXICALLY PLACED ADRENOMEDULLARY-STRIATAL AUTOGRAFTS IN PARKINSONIAN HUMANS - RATIONALE, TECHNIQUES, AND OBSERVATIONS [J].