SYNTHESIS OF FLUORESCEINYL-NEUROKININ-A, A BIOLOGICALLY-ACTIVE PROBE FOR NK2 RECEPTORS

被引：1

作者：

CESZKOWSKI, K

CHOLLET, A

机构：

[1] Glaxo Institute for Molecular Biology S.A., CH-1228 Plan-les-Ouates

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81208-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The tachykinin peptide neurokinin-A has been selectively labelled at a single site with fluorescein isothiocyanate. The fluorescein-labelled neurokinin-A (F-NKA) retained full binding affinity for the NK2 receptor as well as functional activity. F-NKA was used as a tool to study NK2 receptor in cell lines by flow cytometry.

引用

页码：609 / 612

页数：4

共 7 条

[1] ARKINSTALL SJ, UNPUB
[2] CAPPONI AM, 1984, J BIOL CHEM, V259, P8863
[3] RECOMBINANT BOVINE NEUROKININ-2 RECEPTOR STABLY EXPRESSED IN CHINESE-HAMSTER OVARY CELLS COUPLES TO MULTIPLE SIGNAL TRANSDUCTION PATHWAYS
EISTETTER, HR
CHURCH, DJ
MILLS, A
GODFREY, PP
CAPPONI, AM
BREWSTER, R
SCHULZ, MF
KAWASHIMA, E
ARKINSTALL, SJ
[J]. CELL REGULATION, 1991, 2 (10): : 767 - 779
[4] COMPETITIVE ANTAGONISTS DISCRIMINATE BETWEEN NK2 TACHYKININ RECEPTOR SUBTYPES
MAGGI, CA
PATACCHINI, R
GIULIANI, S
ROVERO, P
DION, S
REGOLI, D
GIACHETTI, A
MELI, A
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1990, 100 (03) : 588 - 592
[5] TACHYKININS
MAGGIO, JE
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1988, 11 : 13 - 28
[6] MAMMALIAN TACHYKININ RECEPTORS
NAKANISHI, S
[J]. ANNUAL REVIEW OF NEUROSCIENCE, 1991, 14 : 123 - 136
[7] STRUCTURE-ACTIVITY STUDIES OF NEUROKININ-A
ROVERO, P
PESTELLINI, V
RHALEB, NE
DION, S
ROUISSI, N
TOUSIGNANT, C
TELEMAQUE, S
DRAPEAU, G
REGOLI, D
[J]. NEUROPEPTIDES, 1989, 13 (04) : 263 - 270

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