A NEW METHOD FOR SELECTIVE INTRODUCTION OF TRIFLUOROMETHYL GROUPS INTO HETEROAROMATIC-COMPOUNDS - SYNTHESIS OF TRIFLUOROMETHYLFURANS

被引：11

作者：

BURGER, K

HELMREICH, B

机构：

[1] Organisch-Chemisches Institut, Technischen Universität München, Garching, W‐8046

来源：

JOURNAL FUR PRAKTISCHE CHEMIE-CHEMIKER-ZEITUNG | 1992年 / 334卷 / 04期

关键词：

D O I：

10.1002/prac.19923340404

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Transformation of 4,4-bis(trifluoromethyl)-1-oxabuta-1,3-dienes (2) into 2-fluoro-3-trifluoromethylfurnas (4) can be achieved in a two step procedure by treatment with tin (II) chloride and sodium hydride. The fluorine atom at skeleton position 2 is replaced smoothly by various nucleophiles. The reaction sequence represents a preparatively simple method for the selective introduction of biologically relevant substituents into 3-trifluoromethylfurans.

引用

页码：311 / 316

页数：6

共 47 条

[1] REACTIONS OF N-IMINOPYRIDINIUM YLIDE WITH DIPOLAROPHILES OF THE FLUOROCARBON CLASS - SYNTHESIS OF FLUORINATED 3-AZAINDOLIZINES [J].