THE MATRIX METALLOPROTEINASES AND THEIR NATURAL INHIBITORS - PROSPECTS FOR TREATING DEGENERATIVE TISSUE-DISEASES

被引：197

作者：

DOCHERTY, AJP ^{[1
]}

OCONNELL, J ^{[1
]}

CRABBE, T ^{[1
]}

ANGAL, S ^{[1
]}

MURPHY, G ^{[1
]}

机构：

[1] STRANGEWAYS RES LAB,CAMBRIDGE CB1 4RN,ENGLAND

来源：

TRENDS IN BIOTECHNOLOGY | 1992年 / 10卷 / 06期

关键词：

D O I：

10.1016/0167-7799(92)90214-G

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Uncontrolled matrix metalloproteinase activity is thought to be a cause of the tissue damage observed in many disease processes. None of the drugs currently in use can prevent tissue destruction, and strategies for the development of synthetic inhibitors have been hampered by a poor understanding of the biochemistry of matrix metalloproteinases. Recent cDNA cloning efforts and characterization of recombinant human matrix metalloproteinases have permitted structure-function analysis of the enzymes and their inhibitors. Progress in this area should help indicate a route to rational strategies for designing lead therapeutic compounds.

引用

页码：200 / 207

页数：8

共 77 条

[1] INHIBITION OF COLLAGENOLYTIC ACTIVITY AND METASTASIS OF TUMOR-CELLS BY A RECOMBINANT HUMAN TISSUE INHIBITOR OF METALLOPROTEINASES [J].