A QUANTITATIVE METHOD FOR THE ESTIMATION OF PARTHENOLIDE AND OTHER SESQUITERPENE LACTONES CONTAINING ALPHA-METHYLENEBUTYROLACTONE FUNCTIONS PRESENT IN FEVERFEW, TANACETUM-PARTHENIUM

被引：16

作者：

DOLMAN, DM ^{[1
]}

KNIGHT, DW ^{[1
]}

SALAN, U ^{[1
]}

TOPLIS, D ^{[1
]}

机构：

[1] DEPT CHEM,NOTTINGHAM NG7 2RD,ENGLAND

来源：

PHYTOCHEMICAL ANALYSIS | 1992年 / 3卷 / 01期

关键词：

FEVERFEW; TANACETUM-PARTHENIUM; SESQUITERPENE LACTONES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

D O I：

10.1002/pca.2800030105

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A sensitive and quantitative assay of parthenolide and other sesquiterpene lactones containing an alpha-methylenebutyrolactone residue which are present in Feverfew, Tanacetum parthenium, has been developed. This is based on Michael additions of alkylthiols containing a large chromophore to the latter function. A particularly suitable derivatizing agent is 9-thiomethylanthracene. The adducts are analysed accurately and with great sensitivity using high performance liquid chromatograph coupled with ultraviolet detection.

引用

页码：26 / 31

页数：6

共 16 条

[1] REVISED STRUCTURES FOR GUAIANOLIDE ALPHA-METHYLENEBUTYRO-LACTONES FROM FEVERFEW [J].