CATALYTIC ACTIVITY OF CHIRAL BETA-HYDROXYSULFOXIDES IN THE ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO BENZALDEHYDE

被引:47
作者
CARRENO, MC
RUANO, JLG
MAESTRO, MC
CABREJAS, LMM
机构
[1] Departamento de Química (C-I). Facultad
关键词
D O I
10.1016/S0957-4166(00)80181-0
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The first examples of the use of readily available beta-hydroxysulfoxides 1-8 as chiral catalysts in the enantioselective addition of diethylzinc to benzaldehyde are reported. The increase of the steric hindrance around the chiral ligand OH group improves the e.e. of the obtained 1-phenylpropanol, which is higher with tertiary alcohols (25-45%) than with secondary ones (<23%). The addition of MeAl3 also affords better e.e. (55%).
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页码:727 / 734
页数:8
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